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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
23.03
Human Site:
Y13
Identified Species:
36.19
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
Y13
L
C
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
P8
M
A
T
S
R
Y
E
P
V
A
E
I
G
V
G
Dog
Lupus familis
XP_852360
326
36788
Y13
L
S
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
Y13
L
S
R
A
D
Q
Q
Y
E
C
V
A
E
I
G
Rat
Rattus norvegicus
P35426
303
33780
Y17
A
E
I
G
V
G
A
Y
G
T
V
Y
K
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
Chicken
Gallus gallus
P13863
303
34670
E8
M
E
D
Y
T
K
I
E
K
I
G
E
G
T
Y
Frog
Xenopus laevis
Q91727
319
35666
Y9
S
K
E
M
K
G
Q
Y
E
P
V
A
E
I
G
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
Y10
K
E
S
S
T
Q
Q
Y
E
P
V
A
E
I
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
Y26
G
D
G
D
P
F
N
Y
Q
E
L
N
I
I
G
Honey Bee
Apis mellifera
XP_391955
457
50351
Y154
I
I
G
E
D
A
S
Y
Q
E
L
S
L
I
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
Y14
S
R
S
T
P
E
R
Y
V
Q
A
A
E
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
E8
M
E
Q
Y
E
K
V
E
K
I
G
E
G
T
Y
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
E8
M
D
Q
Y
E
K
V
E
K
I
G
E
G
T
Y
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
Y8
M
S
G
E
L
A
N
Y
K
R
L
E
K
V
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
93.3
13.3
N.A.
0
0
53.3
60
N.A.
20
26.6
N.A.
33.3
P-Site Similarity:
100
N.A.
33.3
93.3
N.A.
93.3
20
N.A.
0
20
53.3
66.6
N.A.
33.3
53.3
N.A.
46.6
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
0
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
33.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
20
0
14
7
0
0
7
7
40
0
7
0
% A
% Cys:
0
7
0
0
0
0
0
0
0
20
0
0
0
0
0
% C
% Asp:
0
14
7
7
27
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
27
7
14
14
7
7
20
34
14
7
27
40
0
0
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
20
7
0
14
0
0
7
0
20
0
27
0
67
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
7
7
0
0
0
7
0
0
20
0
7
7
54
0
% I
% Lys:
7
7
0
0
7
20
0
0
27
0
0
0
14
0
0
% K
% Leu:
20
0
0
0
7
0
0
0
0
0
20
0
7
0
0
% L
% Met:
34
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
14
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
14
0
0
7
0
14
0
0
0
0
0
% P
% Gln:
0
0
14
0
0
27
34
0
14
7
0
0
0
0
0
% Q
% Arg:
0
7
20
0
7
0
7
0
0
7
0
0
0
0
7
% R
% Ser:
14
20
14
14
0
0
7
0
0
0
0
7
0
0
0
% S
% Thr:
0
0
7
7
14
0
0
0
0
7
0
0
0
20
0
% T
% Val:
0
0
0
0
7
0
14
0
14
0
40
0
0
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
20
0
7
0
67
0
0
0
7
0
0
20
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _